Project leader
	Dr David Coghill Phone: +44-1382 204004                                                                             Fax:       +44-1382 346555

Description of the organization:

The University of Dundee is a leading UK institute for medical research. The Dundee Developmental Research Group (DDRG, headed by Dr. David Coghill) specializes in high quality clinical care and research into various child and adolescent neuropsychiatric disorders including ADHD, Conduct Disorder, Depression and Autism Spectrum Disorders. The group’s clinical research is conducted alongside the local Child and Adolescent Mental Health Services with whom they share staff and have strong links. This service receives around 1000 new referrals each year. Drs Coghill, Seth and Graham run the Developmental Disorders Team which is responsible for managing all of the children with ADHD in the region (Current caseload ≈ 800). Clinical trials are conducted within a dedicated children’s clinical trial facility supported by the Scottish Medicines for Children Research Network. As a consequence, research into the efficacy and safety of medication treatment for psychiatric disorders in children and adolescents is on the priority list of research activities.

Previous experience:

The UNIVDUN (Coghill) has been involved, as Principle Investigator, in many international collaborations, including multi‐site international medication trials (e.g. Sonuga‐Barke et al 2007), large scale European observational studies (Coghill et al 2006) and neuropsychopharmacological studies (Coghill, Rhodes &, Matthews 2007). The Centre for Neuroscience has experience in working within FP6 Integrated Projects.

Profile of staff members:

David Coghill (MB ChB MRCPsych) is a child and adolescent psychiatrist and a senior lecturer in Child and Adolescent Psychiatry at the University of Dundee and Honorary Consultant Child and Adolescent Psychiatrist in the Tayside Child and Adolescent Mental Health Service. He has been involved in several clinical trials in children and adolescents with ADHD and Conduct Disorder and is currently the global lead investigator for two large multinational clinical trials. He is also active in genetic, neuropsychological, neuropsychopharmacological and quality of life research.

Keith Matthews (MD, PhD) is Professor of Psychiatry, an adult psychiatrist and Deputy Director of the Division of Medical Sciences at the University of Dundee. He is actively involved in neuropsychological and neuropsychopharmacological studies in children and adolescents and in research into treatment resistant depression and Obsessive Compulsive Disorder in adults.

John Graham (MB, ChB, MRCPsych) is a child and adolescent psychiatrist and Clinical Lecturer in Child and Adolescent Psychiatry. His areas of expertise include pharmacogenomics, assessing adverse events and managing ADHD and mood and anxiety disorders. His doctoral thesis is on the pharmacogenomics of methylphenidate.

Sarah Seth (MB ChB MRCPsych) is a child and adolescent psychiatrist and Clinical Lecturer in Child and Adolescent Psychiatry. Her areas of expertise include neuropsychology and medication research in ADHD, Oppositional Defiant Disorder and Conduct Disorder. Her doctoral thesis is on the cognitive endophenotypes of ADHD.

Helen Smith (MB ChB MRCPsych) is a forensic psychiatrist and Clinical Lecturer in Psychiatry. Her areas of expertise are in Conduct Disorder and antisocial behaviours. Her doctoral thesis is on the cognitive endophenotypes of Conduct Disorder.

Main tasks in the project:

This partner is providing co‐leadership (clinical) on the project (Coghill). UNIVDUN will also have lead responsibility for the development and running of the prospective cohort study (WP3). It will also actively contribute to patient recruitment in WP3 to data management in WP4.