Project leader
	Dr Eric Rosenthal MD FRCP Consultant Paediatric & Adult Congenital Cardiologist Phone: (44) (0)20 7188 4559 Fax:       (44) (0)20 7188 4556 Email: Eric.Rosenthal@gstt.nhs.uk

Description of organization

The Evelina Children’s Hospital (ECH) is attached to St Thomas’ Hospital as part of the Guy’s & St Thomas’ NHS Foundation Trust which together manages all aspects of heart disease from fetal life, through infancy and childhood into adult life. Research takes place into physiological, interventional and surgical aspects of heart disease. There is a large cardiac magnetic resonance unit and echocardiography department. The echocardiography department undertakes all currently used clinical techniques and is leading on the development of 3‐dimensional echocardiography. There is a full electrophysiological service with a special interest in the causes of and prevention of sudden death. There is a large paediatric and adult renal unit that undertakes transplantation at all ages. The paediatric unit has extensive experience in the use of 24 hour ambulatory blood pressure monitoring across the paediatric age range in clinical and research settings. The overall research strategy is contained within the recently established King’s Health Partner’s Academic Health Science Centre that includes Kings College London, Kings College Hospital and the South London and Maudsley NHS Foundation Trusts University directed by Professor Robert Lechler. Together these partners care for the largest population of any Academic Health Science Centre in the UK. Our current research plans are focused on both medical science and translational research and the proposed study complies well with the organization’s strategy.

Previous experience

We are currently involved with large ongoing projects that involve stratification of echocardiographic techniques and ambulatory blood pressure monitoring across the paediatric population.

Profile of staff members

Eric Rosenthal (MD, FRCP) is a paediatric and adult congenital cardiologist with a special interest in electrophysiology. He has received research grants from the British Heart Foundation for basic cardiac research. He has undertaken drug studies and collaborative European and international projects and published over 100 peer‐reviewed papers.

John M Simpson (MD, FRCP) is a fetal and paediatric cardiologist with a special interest in echocardiography. He has received training grants from the British Heart Foundation for echocardiography and leads on the use of 3‐dimensional echocardiography in children with congenital heart disease. He takes part in multi‐centre echocardiographic studies.

Manish Sinha (MB, MRCPCH) is a paediatric nephrologist with a special interest in the investigation and management of hypertension. He has developed techniques to analyze and stratify ambulatory blood pressures in children and adolescents.

Main tasks in this project

ECH will analyze and measure the echocardiographic and ambulatory blood pressure parameters for all participating centres in WP3. It will also actively contribute to the patient recruitment in WP3.