Concerns have been raised in both the scientific literature and mass media that treatment with methylphenidate can result in a range of adverse psychiatric outcomes. Unfortunately the evidence to support these claims is not strong and several important questions remain unanswered.
Clinical experience suggests that low mood is a real but relatively uncommon adverse effect in those taking methylphenidate. Research evidence on these issues is limited. Also data are confounded by the fact that depression and mood lability are common in those with ADHD irrespective of whether they are receiving medication or not. ADDUCE will investigate the link between treatment with metylphenidate and mood disorders.
PSYCHOSIS                                                                                                                                                                Hallucinations and other psychotic symptoms have been reported in children taking methylphenidate but the extent of this and whether methylphenidate is the cause remains unclear. There is a lack of long-term evidence in representative populations. ADDUCE will address these issues within the current study.
SUICIDE                                                                                                                                                                                  Data from the atomoxetine (e.g. Strattera) clinical trials database identified a small but statistically significant increased risk of suicidal thoughts among atomoxetine-treated children and adolescents compared with patients taking placebo. However, a recent review of the safety literature for ADHD medications found no evidence to suggest that methylphenidate is associated with an increased risk of suicidal thoughts or acts but this is due to a lack of evidence rather than convincing evidence of an absence of risk. ADDUCE will address this in the present study.
TICS AND TOURETTE DISORDER                                                                                                                                          Studies indicate that in 5-10% of cases, tics may get worse in patients treated with metylphenidate. This effect is usually reversible once they stop taking the medication. However, more evidence is needed. ADDUCE will systematically assess tics using reliable, validated measures in ADHD patients treated with methylphenidate and in untreated ADHD controls.
SUBSTANCE MISUSE                                                                                                                                                                Findings from animal studies suggest that the rewarding properties of methylphenidate are diminished  by prior exposure to the drug, and this may increase the risk of later substance misuse. On the other hand, the timing of initial exposure to metylphenidate seems to be an important factor. For instance, whilst metylphenidate treatment in adolescent or adult rats was associated with increased levels of subsequent drug abuse, treatment in preadolescent rats produced the opposite result. Clinical surveillance of humans has not yet established an influence of either short term or long-term use of methylphenidate on substance misuse, as it is difficult to establish the level of substance misuse by an individual. It is also probable that substance misuse is associated with ADHD even in the absence of stimulant medication, and that the presence of conduct disorder can be an additional complicating factor. ADDUCE will use standardised measures of substance use/misuse to address these issues.


The fifth ADDUCE Newsletter is now available!

Here, you can read about the finalisation of the project,

the European Medicines Agency and General Assembly meetings

and the dissemination of the results!

The fourth ADDUCE Newsletter is available!
In this newsletter, you can find some information on the final recruitment status of the 2 main studies:
- the prospective open-label methylphenidate pharmacovigilance study

- the long-term cardiascular effects of methylphenidate use
Also, you can read about the future plans of the project!

More than 1500 children, adolescents and adults across all Europe already took part in our study! Thanks to them, we have already gathered lots of information so we can know a lot more about methylphenidate than ever before! 


Did you participate in the ADDUCE studies and are you curious about the latest news on the project?

Here you can find some information!

News for children, April 2015

News for adolescents, April 2015

News for parents, April 2015

The third ADDUCE Newsletter is available!

Read more about the ADDUCE studies:

- the prospective open-label methylphenidate pharmacovigilance study: recruitment status and spin-
off studies
- the long-term cardiovascular effects of methylphenidate use: study design and participation

and much more in the ADDUCE Newsletter 3, March 2015


The second ADDUCE Newsletter is available!
Read more about the 2 main ADDUCE studies:

  • WP3: prospective open-label methylphenidate
    pharmacovigilance study
  • WP8: long-term cardiovascular effects of methylphenidate use

and much more in the ADDUCE Newsletter 2, February 2013


16 - 19 OCTOBER 2016:

4rd EUNETHYDIS International Conference on ADHD, Berlin - Germany
from basis neuroscience to optimised clinical care

17 & 18 APRIL 2016:

ADDUCE Consortium meeting, London - UK

28 - 31 MAY 2015:

5th World Congress on ADHD: from Child to Adult Disorder, Glasgow - Scotland

20 & 21 APRIL 2015:

ADDUCE Consortium meeting, Salina - Italy

21 - 24 MAY 2014:

3rd EUNETHYDIS International Conference on ADHD, Istanbul - Turkey
ADHD and related disorders

19 & 20 MAY 2014:

ADDUCE Consortium meeting, Istanbul - Turkey

3 - 6 OCTOBER 2013:

23rd EUNETHYDIS Network Meeting, Prague Czech Republic
A meeting of the European Network of Hyperkinetic Disorders

6 - 9 JUNE 2013:            

4th World Congress on ADHD: from Childhood to Adult Disease, Milan - Italy

4 & 5 JUNE 2013:

ADDUCE Consortium meeting, Milan - Italy

 6 & 7 JUNE 2012:            

ADDUCE Consortium meeting, Cagliari - Italy

23 MAY 2012:

2nd EUNETHYDIS International Conference on ADHD, Barcelona - Spain